GeNESiS: gene network evolution simulation software

The genesis and evolution of the African Field Epidemiology Network

In an effort to contain the frequently devastating epidemics in sub-Saharan Africa, the World Health Organization (WHO) Regional Office for Africa launched the Integrated Disease Surveillance and Response (IDSR) strategy in an effort to strengthen surveillance and response. However, 36 sub-Saharan African countries have been described as experiencing a human resource crisis by the WHO. Given th...

The GENESIS Simulation System

GENESIS: genome evolution scenarios

SUMMARY We implemented a software tool called GENESIS for three different genome rearrangement problems: Sorting a unichromosomal genome by weighted reversals and transpositions (SwRT), sorting a multichromosomal genome by reversals, translocations, fusions and fissions (SRTl), and sorting a multichromosomal genome by weighted reversals, translocations, fusions, fissions and transpositions (SwR...

Qualitative Simulation of Software Evolution Processes

Lehman's studies identified the software evolution phenomenon and led to a set of statements termed laws of software evolution [Leh85,Som92,Mdh02]. The term laws was used to highlight that they reflect forces largely independent of the technology used and outside the immediate control of the those implementing the evolution of a system. Over the years the laws have been the basis of a number of...

Qualitative simulation of models of software evolution

Lehman’s laws and the quantitative models related to them seek to encapsulate empirical generalisations about E-type program evolution. Such modelling is hampered by insufficient knowledge about the mechanisms at work and their parameters. Qualitative reasoning is an approach that tackles lack of precise knowledge by reasoning at a more abstract level than one does in quantitative modelling. Th...